Skip to content

A study to see the effect of two drugs, norepinephrine and mephentermine for maintenance of blood pressure during caesarean section.

Intravenous Norepinephrine & Mephentermine for maintenance of blood pressure during spinal anaesthesia for caesarean section: An Interventional study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/06/019652
Enrollment
168
Registered
2019-06-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: Injection Norepinephrine: Injection Norepinephrine 8 microgram intravenous is given to treat hypotension Intervention2: Injection Mephentermine: Injection Mephentermine 6mg intravenous

Sponsors

Dr PJ Shah
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA Physical status â??Ð?Ð? 2. Singleton pregnancy 3. Term Pregnancy 4. Elective Cesarean Delivery 5. Weight 50-100kg 6. Height 140-180 cm 7. Age 18-35 years

Exclusion criteria

Exclusion criteria: 1.Pre-existing or Pregnancy induced Hypertension 2.Known fetal abnormality 3.Cardiovascular or Cerebrovascular disease 4.Gestational Diabetes Mellitus 5.Renal Impairment 6.Allergy to Norepinephrine & Mephentermine 7. Medication- MAO Inhibitors or TCA 8.Intraoperative use of uterotonic other than oxytocin 9.Presence of mesenteric or peripheral vascular thrombosis

Design outcomes

Primary

MeasureTime frame
Maternal Systolic Blood PressureTimepoint: At every 2 minutes after administration of spinal anaesthesia till 20 minutes and every 5 minutes there after till completion of surgery.

Secondary

MeasureTime frame
Maternal diastolic blood pressure,Maternal mean blood pressure,Maternal heart rate,Total dose of vasopressor required for correction of hypotension Timepoint: At every 2 minutes after administration of spinal anaesthesia till 20 minutes and every 5 minutes there after till completion of surgery.

Countries

India

Contacts

Public ContactDr Rajesh Kumar Beldar

Department of Anaesthesiolgy, Pt. J.N.M. Medical College, Raipur(C.G.)

prati_jain@rediffmail.com9827276620

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 25, 2026