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A study to assess if neutrophil-lymphocyte ratio and platelet-lymphocyte ratio can be used to predict chronic kidney disease in patients with type 2 diabetes.

Neutrophil-lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) as predictive markers for chronic kidney disease in persons with type 2 diabetes

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/06/019629
Enrollment
317
Registered
2019-06-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E112- Type 2 diabetes mellitus with kidney complications Health Condition 2: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Dr Vignesh Kumar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Persons with type 2 diabetes without nephropathy or other complications 2. Persons with type 2 diabetes with CKD

Exclusion criteria

Exclusion criteria: 1. Patients having low glomerular filtration rate (GFR) without microalbuminuria will be excluded from the study. 2. Patients with type 1 DM 3. Febrile patients/patients with infections including urinary tract infection (UTI), respiratory tract infections, gastrointestinal infection, otitis media, viral hepatitis, parasitic infection, viral infection, tuberculosis, local infection, skin infection, AIDS, pyrexia of unknown origin, and any other infectious disease. 4. Patients with systemic disorder such as cardiovascular disease, chronic liver disease, blood disorders, autoimmune disorders, malignancy, poisoning; 5. Patients on anti-inflammatory drugs, systemic or topical steroids, alcohol; 6. Patients with uncontrolled blood pressure (BP); 7. Patients having diseases affecting urinary protein excretion as nephritic syndrome, urolithiasis, renal insufficiency, renal artery stenosis, dehydration state, and UTI

Design outcomes

Primary

MeasureTime frame
The association of Neutrophil Lymphocyte Ratio and Renal function will be studied. Predictive value of Neutrophil Lymphocyte ratio for Chronic Kidney disease in diabetics will be assessed and compared to that of Platelet Lymphocyte ratio, High Sensitive C Reactive Protein, and Urine MicroalbuminuriaTimepoint: 18 months

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactVignesh Kumar

Dr. TMA Pai Hospital

shashikiran.u@manipal.edu9008418171

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026