Health Condition 1: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: TIPS with vasoactive drug: The most common approach is through the right internal jugular approach.
After infiltrating the puncture site with 2% lignocaine and puncturing the vein a gui
Sponsors
Institute of Liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Consecutive patients of cirrhosis aged 18-70 years presenting with acute variceal Bleeding, who on endoscopy fail to control bleed or rebleeds within 5 days will be randomized.
Exclusion criteria
Exclusion criteria: 1. Bleeding from non-variceal source 2. Coagulopathy related bleed 3. Bleeding from Gastric varices 4. Any malignancy including HCC 5. Main Portal vein thrombosis 6. Patients in refractory shock 7. Patients with severe cardiopulmonary disease 8. Grade 4 Hepatic encephalopathy 9. MELD > 25 10.Multiorgan failure 11.Active sepsis 12.Pregnancy 13. Failure to give consent
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Adverse events in both groupsTimepoint: 6 weeks;Decompensation in both groups in the form of ascites or Hepatic EncephalopathyTimepoint: 6 weeks;Re-bleeding in both groups for 5 days from end of therapyTimepoint: 5 days;Rebleeding in both groupsTimepoint: 6 weeks;Worsening of liver severity score in both groups.Timepoint: 6 weeks | — |
Primary
| Measure | Time frame |
|---|---|
| Survival in both groupsTimepoint: 6 weeks | — |
Countries
India
Contacts
Public ContactDr Shushrut Singh
Institute of Liver and Biliary Sciences
Outcome results
None listed