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To compare the effectiveness of oral itraconazole with low dose and high dose isotretinoin in the treatment of tinea

Comparative efficacy of oral Itraconazole alone and in combination with low dose and high dose Isotretinoin in the treatment of dermatophytosis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/06/019600
Enrollment
90
Registered
2019-06-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B359- Dermatophytosis, unspecified

Interventions

Intervention1: Oral itraconazole: Patients will be given oral capsule itraconazole 100 mg twice daily for a period of four weeks Control Intervention1: Oral itraconazole with oral isotretinoin: Patien

Sponsors

Department of dermatology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. KOH positivity on direct microscopy showing septate hyphae of dermAtophytosis . 2. Patients with extensive disease requiring systemic therapy . 3. Patients above 18 years of age .

Exclusion criteria

Exclusion criteria: 1. Patients with co-existing dermatophytosis involving hairs, nail, palms and soles. 2. Patients with hepatic , renal derangement , abnormal lipidvprofile or any significant systemic illness. 3. Patients on immunosuppressive agents. 4. Pregnant and lactating women . 5. Women of child bearing age not using contraception indicated for systemic retinoids therapy .

Design outcomes

Primary

MeasureTime frame
Compare the therapeutic efficacy of concomitant use of low and high dose isotretinoin along with itraconazole in dermatophytosisTimepoint: 0,2,4,8 weeks—

Secondary

MeasureTime frame
To look for adverse effects of combination of Itraconazole and IsotretinoinTimepoint: 0,2,4,8 weeks—

Countries

India

Contacts

Public ContactDr Shradha

Government Medical College and Hospital , sector 32, chandigarh

malabhalla@yahoo.co.in9646121545

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026