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Major Adverse Cardiac Events occurring during non cardiac surgery in cardiac patients: How accurately cardiac biomarkers predict the occurrence of these Events?

Perioperative Major Adverse Cardiac Events in high risk patients undergoing major non cardiac surgeries: how accurately does pro-BNP and cardiac Troponin T predict the occurrence of major adverse cardiac events?

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/06/019599
Enrollment
500
Registered
2019-06-10
Start date
Unknown
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery

Interventions

Intervention1: nil: nil

Sponsors

Postgraduate Institute of Medical Education and Research Chandigarh
Lead Sponsor
Prof GD Puri
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Patients with prior history of coronary artery disease will be defined as having any one of the following: i) Definite CAD as indicated by a previous history of MI, typical angina or ECG changes suggestive of previous MI without a documented history of MI ii) Patient who underwent coronary artery reperfusion therapy including previous fibrinolytic therapy, percutaneous coronary intervention and coronary angioplasty. Patient at risk of coronary artery disease will be defined as those with age 45 yr or older and had at least one of the following major cardiac risk factors34: 1) Diabetes mellitus 2) Peripheral artery disease (i.e. intermittent claudication or history of vascular surgery except arteriovenous shunt and vein-stripping procedures) 3) History of hospitalization for congestive heart failure 4) Renal insufficiency (defined as preoperative creatinine >150 µmol litre-1) 5) History of cerebral vascular event 6) Aortic valve stenosis (defined as aortic valve area 7) Atrial fibrillation 8) Moderate or poor left ventricular function (defined as left ventricular ejection fraction

Exclusion criteria

Exclusion criteria: Patients will be excluded from study participation if they had no signed informed consent.

Design outcomes

Primary

MeasureTime frame
The primary outcome of our study is to determine the incidence of perioperative Major Adverse Cardiac Events in cardiac patients undergoing non cardiac surgery and all cause 30 day and 1 year mortality rate in these patients.Timepoint: 30 days and 1 year—

Secondary

MeasureTime frame
The secondary outcome is to determine whether high sensitive cardiac troponin T or pro-BNP is more accurate in predicting Major Adverse cardiac Events.Timepoint: At preoperative stage, 24 hours following surgery and 72 hours following surgery.—

Countries

India

Contacts

Public ContactNitika Goel

Postgraduate Institute of Medical Education and Research, Chandigarh

nitikagoel7@gmail.com01722726500

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026