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A study to assess cartilage growth after platelet rich plasma injection for treatment of knee osteoarthritis

Radiological assessment of cartilage regeneration after intra-articular platelet-rich plasma (PRP) injection for early osteoarthritis of the knee: a prospective clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/06/019593
Enrollment
44
Registered
2019-06-10
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: Intra articular PRP injection: 5 ml PRP injected in osteoarthritic knee joint Control Intervention1: NOT APPLICABLE: NOT APPLICABLE

Sponsors

Institute of Medical Sciences BHU Varanasi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 40 years to 80 years 2. Clinically and radiologically diagnosed knee OA (American College of Rheumatology Diagnostic Criteria2) with Kellgren and Lawrence radiographic classification8 grade 2 or presence of 1-2 posterior or lateral osteophytes on a posteroanterior view (Early OA) 3. Not responding to conservative management (medications, physical therapy) for at least 6 months

Exclusion criteria

Exclusion criteria: 1. Inflammatory causes of knee arthritis ( rheumatoid, gout ) 2. Presence of loose bodies in knee joint, crystal arthropathies or tense joint effusion 3. History of a previous knee joint injection within 3 months or surgery in the past 4. Co-existence of a neuropathic component of pain ( PainDetect pain score of >12 )9 5. Thrombocytopenia (platelet count 6. Systemic diseases-Hematologic/ bone malignancy, infection, immunosuppressive status 7. History of smoking

Design outcomes

Primary

MeasureTime frame
1. Amount of cartilage growth after intra-articular PRP injection for treatment of knee osteoarthritis 2. Efficacy of MRI and USG as tools for measuring cartilage dimensionsTimepoint: Baseline, 6 months—

Secondary

MeasureTime frame
1. Correlation of platelet count in the injected sample with joint cartilage growth and improvement in knee pain 2. Numerical Rating Scale (NRS) for pain and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score 3. Variation in analgesic requirement over time 4. Complications and adverse effectsTimepoint: Baseline,3 months, 6 months—

Countries

India

Contacts

Public ContactDr Nimisha Verma

Sir sunderlal hospital, BHU

verma.nimisha5@gmail.com9559955988

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026