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To study effect of Vitamin D supplementation on atherosclerotic risk factors (endothelial dysfunction) in post-renal transplant patients.

Impact of Vitamin D Supplementation on Endothelial Function in Renal-Transplant Recipients- A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/06/019565
Enrollment
120
Registered
2019-06-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N186- End stage renal disease

Interventions

Intervention1: Vitamin D supplementation: Cholecalciferol- 60,000u once a week for 12 weeks Control Intervention1: placebo: placebo- once a week for 12 weeks

Sponsors

PGIMER Chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age group 18-60 years 2.Patients with stable renal functions (serum creatinine 6 months) 3.With Vitamin D deficiency (

Exclusion criteria

Exclusion criteria: 1.Patients refusing consent 2.Patients with prior history of atherosclerosis- coronary artery disease/ cerebrovascular accidents 3.Patients with basic disease as diabetes mellitus 4.Patients with past malignancies/ granulomatous infections 5.Patient with history of intake of Vitamin D in the last 30 days 6.Patients with pregnancy

Design outcomes

Primary

MeasureTime frame
The effect of vitamin D (Cholecalciferol) supplementation on endothelial function via brachial FMD in renal transplant cases with Vitamin D deficiency versus a placebo-controlled arm.Timepoint: 12 weeks—

Secondary

MeasureTime frame
1. Difference in NMD, CD28 null cells and PWV between the two study arms. 2. The effect of vitamin D (Cholecalciferol) supplementation in the previously placebo arm (after crossover) on endothelial function (FMD, CD28 null cells and PWV). Timepoint: 12 weeks 24 weeks—

Countries

India

Contacts

Public ContactDr Raja Ramachandran

Post Graduate Institute of Medical Education and Research, Chandigarh

drraja1980@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026