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To assess levels of stress, serum and salivary Ghrelin and Cortisol in Stage III Periodontitis with smokers and non- smokersâ?? A Cross-sectional Study.

Evaluation of Stress, Serum and Salivary Ghrelin and Cortisol Levels in Smokers and Non-smokers with Stage III Periodontitis.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/06/019542
Enrollment
90
Registered
2019-06-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Control Intervention1: Nil: This is an observational trial. In this study we will compare the serum and salivary ghrelin and cortisol levels in periodontally healthy patients with smokers and non-smok

Sponsors

Self
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group I: Periodontally healthy subjects with no signs of periodontal disease and smoking. Group II: Current Smokers with untreated stage III periodontitis, PPD >= 6 mm and CAL >= 5mm. Group III: Non-smokers with untreated stage III periodontitis, PPD >= 6mm and CAL >= 5mm.

Exclusion criteria

Exclusion criteria: 1. Patients with self-reported psychiatric disorders or on anti-psychotic medications. 2. Patients with any systemic disease. 3. Pregnant and post-menopausal women. 4. Patients with history of antibiotic intake within 6 weeks. 5. Patients undergoing corticosteroids or immune-suppressive therapy. 6. Patients with symptoms of acute illness.

Design outcomes

Primary

MeasureTime frame
To evaluate the stress, serum and salivary cortisol and ghrelin levels in smokers and non-smokers with stage III periodontitis.Timepoint: 18 months—

Secondary

MeasureTime frame
To evaluate and compare the serum and salivary ghrelin and cortisol levels in periodontally healthy patients, smokers and non-smokers with stage III periodontitis.Timepoint: 18 months—

Countries

India

Contacts

Public ContactDr Abhay Kolte

Department of Periodontology and Implantology, VSPM Dental College and Research Centre, Nagpur

drrajashrikolte@gmail.com9011071468

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026