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Comparison of effect of pre-operative nebulisation with two different medicines in reducing post-operative sore throat

Reduction in post-operative sore throat after pre-operative nebulisation with Dexmedetomidine or Ketamine: A prospective, randomized, double-blinded, placebo controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/06/019540
Enrollment
132
Registered
2019-06-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K402- Bilateral inguinal hernia, withoutobstruction or gangrene Health Condition 2: K811- Chronic cholecystitis Health Condition 3: N979- Female infertility, unspecified Health Condition 4: N839- Noninflammatory disorder of ovary,fallopian tube and broad ligament, unspecified Health Condition 5: N849- Polyp of female genital tract, unspecified Health Condition 6: K409- Unilateral inguinal hernia, without obstruction or gangrene

Interventions

Intervention1: DEXMEDETOMIDINE: After taking written,informed consent, patients randomly allocated to group D will receive dexmedetomidine nebulisation 2 microgram per Kg ,15 min prior to induction of

Sponsors

none
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I&II patients undergoing laproscopic surgeries under general anaesthesia lasting up to two hours requiring endotracheal intubation

Exclusion criteria

Exclusion criteria: Difficult laryngoscopy or more than 1 attempt at intubation,patients on steroid or NSAID,pre existing pharyngeal or laryngeal disease,upper airway surgeries,surgeries requiring insertion of throat pack intra operatively,more than one attempt to pass orogastric or nasogastric tube,patients refusing consent

Design outcomes

Primary

MeasureTime frame
Reduction in incidence and severity of post operative sore throatTimepoint: 2,6,12,24 hours post surgery—

Secondary

MeasureTime frame
Haemodynamic changes in the study groupTimepoint: During pre operative assessment,before induction of anaesthesia,post -laryngoscopy,at 15 minute interval intraoperatively,after shifting to post anesthesia care unit;Post operative analgesia among the study groupsTimepoint: 2,6,12,24 hours after shifting to post anaesthesia care unit;post operative nausea and vomiting among the study groupsTimepoint: 2,6,12,24 hours after shifting to post anaesthesia care unit;Post operative sedation among the study groupsTimepoint: 2,6,12,24 hours after shifting to post anaesthesia care unit—

Countries

India

Contacts

Public ContactDr PRIYANKA GUPTA

ALL INDIA INSTITUTE OF MEDICAL SCIENCES ,RISHIKESH

drpriyankagupta84@gmail.com9811894899

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026