Health Condition 1: E116- Type 2 diabetes mellitus with other specified complications
Conditions
Interventions
Intervention1: Non surgical periodontal therapy in chronic periodontitis patients with Type 2 Diabetes mellitus (good control patients with HbA1c less than 7% and poor control patients with HbA1c more
Sponsors
Gayathri K
Eligibility
Inclusion criteria
Inclusion criteria: 1.Minimum number of 15 teeth should be present. 2.Patients with Generalised Chronic periodontitis exhibiting Probing Pocket depth of more than or equal to 4mm with Clinical attachment level of more than or equal to 3mm in more than 30percent of diseased sites, According to the AAP 1999 World Workshop (Group I) 3.If more than five sites satisfy the criteria, sample sites were selected based on greater amount of gingival inflammation, probing pocket depth and clinical attachment level. 4.Chronic periodontitis patient with Type 2 diabetes mellitus exhibiting good and poor control. According to American Diabetic Association(ADA) classification of glycaemic control- a) Subjects with HbA1c below 7% , as Type 2 diabetics with good control in one group(group II) b) Subjects with HbA1c more than 8% , as Type 2 diabetics with poor control in another group(group III)
Exclusion criteria
Exclusion criteria: 1.Patients with other systemic condition or diseases influencing the course of periodontal disease other than diabetes. 2.Patients with haemoglobinopathies, bleeding and clotting disorders that will influence HbA1c level. 3.History of periodontal treatment within the previous six months 4.Antimicrobial therapy immunosuppressants or lipid lowering drugs within the past 3months 5.Current Smokers who have smoked more than or equal to 100 cigarettes in their lifetime and currently smoke,Former smokers have smoked more than or equal to 100 cigarettes 6.Heavy alcoholics 7.Pregnancy and Lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To evaluate the levels of Endocan and TNF-alpha in gingival crevicular fluid in systemically healthy Chronic Periodontitis subjects 2.To evaluate the levels of Endocan and TNF-alpha in gingival crevicular fluid in chronic periodontitis subjects with well controlled diabetes mellitus (HbA1C less than 7). 3.To evaluate the levels of Endocan and TNF-alpha in gingival crevicular fluid in chronic periodontitis subjects with poorly controlled diabetes mellitus (HbA1C more than 8). Timepoint: At baseline and after 3months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To compare the levels of Endocan and TNF-alpha between study groups. 2.To Correlate Endocan and TNF-alpha levels with the periodontal clinical parameters in all the groups before and after non-surgical periodontal therapy Timepoint: At baseline and at 3months | — |
Countries
India
Contacts
Public ContactGayathri K
SRM DENTAL COLLEGE,RAMAPURAM
Outcome results
None listed