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Comparison of regional cerebral oxygen saturation variations between "sevoflurane" and "propofol" anaesthesia in gynaecological laparoscopic surgery

Comparison of regional cerebral oxygen saturation variations between Sevoflurane and Propofol anaesthesia in Gynaecological laparoscopic surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/05/019468
Enrollment
34
Registered
2019-05-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N809- Endometriosis, unspecified Health Condition 2: N819- Female genital prolapse, unspecified Health Condition 3: N979- Female infertility, unspecified

Interventions

Control Intervention1: Sevoflurane: Inhalational anaesthetic agent for maintenance of general anaesthesia Control Intervention2: Propofol: Intravenous anaesthetic agent for maintenance of general anae

Sponsors

Ipgmer and Sskm Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Adult women undergoing gynaecological laparoscopic surgery under general anaesthesia 2) Age between 18-60years 3) ASA status of I or II 4) BMI

Exclusion criteria

Exclusion criteria: 1) Patient refusal 2) A history of cerebrovascular disease 3) Patients on antipsychotic drugs 4) History of drug abuse 5) Significant cardiovascular and respiratory diseases 6) Any pre-existing neurological disorders 7) Poorly controlled hypertension 8) Obesity (Body Mass Index >30)

Design outcomes

Primary

MeasureTime frame
rSO2Timepoint: rSO2 values will be recorded just before pneumoperitoneum in the neutral position (TN), 5 minutes after the pneumoperitoneum (TP), 5 minutes after the Trendelenburg position(TT) and 5 minutes after desufflation in the neutral position(TD).—

Secondary

MeasureTime frame
MAP, HR, oxygen saturation (SpO2), ETCO2, end-tidal sevoflurane tension (ETsevo), core body temperature, Haemoglobin (Hb%), BIS, arterial oxygen partial pressure (PaO2), and arterial carbon dioxide partial pressure (PaCO2)Timepoint: just before pneumoperitoneum in the neutral position (TN), 5 minutes after the pneumoperitoneum (TP), 5 minutes after the Trendelenburg position(TT) and 5 minutes after desufflation in the neutral position(TD).—

Countries

India

Contacts

Public ContactAtul Aman

ipgmer & sskm hospital

contactdratul@gmail.com09088955257

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026