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Comparison of POCD between Propofol induction and Ketofol induction

Comparative evaluation of effect of propofol and ketofol induction on the incidence of postoperative cognitive dysfunction in adults undergoing general anesthesia- a double blinded randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/05/019456
Enrollment
100
Registered
2019-05-30
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: PROPOFOL INDUCTION: PROPOFOL, INTRAVENOUS ROUTE OF ADMINISTRATION, IS USED FOR GENERAL ANESTHESIA INDUCTION. TOTAL DURATION IS LESS THAN 2 HOURS Control Intervention1: KETOFOL: PROPOFOL

Sponsors

Deen dayal upadhyay hospital New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 AND 2 SURGERY NOT EXPECTED TO CROSS 2 HOURS EDUCATION ATLEAST 10TH STANDARD PASS

Exclusion criteria

Exclusion criteria: PATIENT REFUSAL HISTORY OF KNOWN ALLERGY TO DRUGS BEING USED HISTORY OF PSYCHIATRIC ILLNESS DRUG OR ALCOHOL ABUSE AND CHRONIC PAIN HISTORY OF TREATMENT WITH ANTIANXIETY OOPIIOD ANTICONVULSANTS AND ANTIPYSCHOTIC DRUGS PREGNANT AND LACTATING WOMEN PATIENT WITH HISTORY OF ALZHEIMERS DISEASE AND MMSE SCORE LESS THEN 23

Design outcomes

Primary

MeasureTime frame
TO OBSERVE THE INCIDENCE OF POST OPERATIVE COGNITIVEDYSFUNCTION AS PER POSITIVE NEUROPSYCHOLOGICAL TESTS IN BOTH THE GROUPSTimepoint: POST OPERATIVE 5 MINS, 30 MINS , 1 HOUR, 2 HOUR AND 4 HOUR—

Secondary

MeasureTime frame
To correlate Richmond agitation sedation scale wth incidence of positive neuropsychological tests for POCD. To assess the relation of age and education on POCD in ketofol and propofol group. To copare hemodynamic parameterrs in ketofol and propofol groups upto 4 hours postoperatively.Timepoint: Intraoperatively and 4 hours of podstoperative period—

Countries

India

Contacts

Public ContactBHARATH BK

Deen dayal upadhyay hospital

babbarrl@gmail.com9718990110

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026