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Comparison of effects of blood pressure increasing medications on maintenance of blood pressure during cesarean section under spinal anaesthesia.

Effects of prophylactic bolus of norepinephrine versus phenylephrine on maternal and foetal outcome during caesarean section under subarachnoid block: a randomised study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/05/019426
Enrollment
240
Registered
2019-05-29
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O80- Encounter for full-term uncomplicated delivery

Interventions

Intervention1: Group 2 (Phenylephrine group): Parturients will receive bolus dose of phenylephrine 50 mcg immediately after spinal anaesthesia Intervention2: Group 1 (Norepinephrine group): Parturient

Sponsors

Department of Anaesthesiology Pain and Perioperative medicine
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Term pregnancy (>=37 weeks) planned for caesarean section under subarachnoid block 2. Age >18 years 3. ASA physical status I or II [29] 4. Weight >50 kg or 5. Height >150cm or 6. Singleton pregnancy

Exclusion criteria

Exclusion criteria: 1. Pre-eclampsia 2. Haemoglobin 3. Resting heart rate > 120/min 4. History of cardiovascular diseases ( hypertension, arrhythmia, ischaemic and valvular heart disease, cardiomyopathy) 5. History of cerebrovascular disease 6. Renal impairment (Sr. Creatinine > 1.2mg/dL) 7. Allergy to local anaesthetic agents or opioids 8. Thrombocytopenia (Platelet count 1.5) 9. Previously known foetal abnormality (syndromic issues, small for gestational age) 10. Refuse to give consent

Design outcomes

Primary

MeasureTime frame
To compare the effects of norepinephrine with phenylephrine on the incidence of maternal hypotension following subarachnoid block in parturients undergoing elective caesarean deliveryTimepoint: From subarachnoid block to delivery of baby—

Secondary

MeasureTime frame
To compare the effects of norepinephrine with phenylephrine among the parturients undergoing elective caesarean delivery under subarachnoid block on: 1. Maternal heart rate (HR) 2. Incidence of reactive hypertension 3. Incidence of maternal intraoperative nausea or vomiting ( IONV) 4. Neonatal Apgar score 5. Umbilical cord blood pH 6. Need for active neonatal resuscitation Timepoint: From subarachnoid block to delivery of baby—

Countries

India

Contacts

Public ContactDr Shweta Sinha

Sir Ganga Ram Hospital

anjeleenasgrh@gmail.com9818422867

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026