To compare bone loss that occurs in immediate ( crown given within 48 hrs) and delayed (crown given after 3 months) loaded dental implants with osteocalcin collected from giniva at different time inetrvals

To Correlate the level of Osteocalcin in Peri-implant crevicular Fluid with Crestal Bone Loss at Different time intervals in immediate and Delayed loaded Dental Implants. A Randomized Controlled Pilot Study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/05/019411

Enrollment

Registered

2019-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K084- Partial loss of teeth

Interventions

Intervention1: Immediate loading done on one side as per randomization: bilateral implants placed on lower jaw and immediate loading is done on one side determined by randomization. bone loss and oste

Eligibility

Inclusion criteria

Inclusion criteria: 1.Bilateral missing mandibular molars or second premolars 2.Same occlusal scheme on right and left side with either canine guided or group function. 3.Sufficient available bone in terms of quality and quantity. 4.Free from systemic diseases affecting gingival health and osseointegration 5.Positive informed consent.

Exclusion criteria

Exclusion criteria: 1.General contraindication to implant surgery 2.History of smoking, drug, tobacco and alcohol abuse 3.Parafunctional habits. 4.Irradiated patient. 5.Pregnancy 6 >Presence of systemic or congenital diseases that affects bone metabolism or immune system 7.Implant insertion torque less than 35 Ncm

Design outcomes

Primary

Measure	Time frame
1.To estimate and compare the level of osteocalcin in PICF at 2 weeks, 3 months and 12 months in immediate and delayed loaded dental implants. 2.To evaluate and compare the crestal bone loss radiographically (IOPA) at different time intervals in immediate and delayed loaded dental implants. 3.To correlate the crestal bone loss with osteocalcin levels in PICF. Timepoint: 2 weeks 3 months 1 year	—

Secondary

Measure	Time frame
1. To evaluate the soft tissue response (modified gingival index and probing pocket depth) at different time intervals at 2weeks, 3 months and 12months in immediate and delayed loaded dental implantsTimepoint: 2 weeks 3 months 1 year	—

Countries

India

Contacts

Public ContactDr Veena Jain

Cder Aiims

jainveena1@gmail.com9868187441

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026