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â??Comparative Clinical and Radiographic Evaluation of the Efficacy of A-PRF plus with DFDBA (donor bone graft from other humans) v/s iPRF with DFDBA used in the Treatment of Periodontal Defects within Bone in Periodontitis Patients- A Randomized Clinical Trialâ??

â??Comparative Clinical and Radiographic Evaluation of the Efficacy of Autologous Advanced Platelet-Rich Fibrin (A-PRF+) with Demineralized Freeze-Dried Bone Allograft (DFDBA) v/s Autologous Injectable Platelet-Rich Fibrin (iPRF) with DFDBA used in the Treatment of Intrabony Defects in Chronic Periodontitis Patients- A Randomized Clinical Trialâ??

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/05/019379
Enrollment
40
Registered
2019-05-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

Intervention1: Autologous injectable Platelet-Rich Fibrin (iPRF) with demineralized freeze-dried bone allograft (DFDBA): Prepared by centrifugation of patients blood (20 ml) at 700 rpm for 3 minutes.

Sponsors

Dr Ruthali Vithal Kamat
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients in the age group between 20-60years. 2) Patients diagnosed with chronic periodontitis. 3) Patients who are non-smokers or do not consume tobacco in any other form 4) Patients are in good systemic health with no contraindication to periodontal surgery. 5) Patients having pocket depths >5mm, intraosseous defects > 3mm and with radiographic evidence of vertical / angular bone loss in the affected sites. 6) Involved teeth to be free of any endodontic lesion.

Exclusion criteria

Exclusion criteria: 1) One-walled osseous defects. 2) Patients suffering from any systemic diseases or with a compromised immune system. 3) Patients who had received any type of periodontal therapy for the past 6 months. 4) Patients taking immunosuppressant drugs like corticosteroids. 5) Patients with a known history of allergy to Doxycycline or Chlorhexidine or any other medicine used in the study. 6) Patients showing unacceptable oral hygiene compliance during / after Phase I periodontal therapy. 7) Patients taking any drug known to cause gingival enlargement. 8) Pregnant and/or lactating mothers. 9) Patients who were smokers or had tobacco in any other form. 10) Patients on anticoagulant therapy. 11) Patients with bleeding disorders. 12) Endodontically treated teeth

Design outcomes

Primary

MeasureTime frame
1. Plaque Index (P.I.) (Tureskey-Gilmore-Glickman Modification of Quigley Hein 2. Gingival Index (G.I.) (Loe and Silness, 1963) 3. Probing Pocket Depth (PPD) 4. Clinical Attachment Level (CAL) Timepoint: 1. PI- at baseline (pre-surgery), 1 month post-surgery, 3 months post-surgery, and 6 months post-surgery. 2. GI-at baseline (pre-surgery), 1 month post-surgery, 3 months post-surgery, and 6 months post-surgery. 3. PPD-at baseline (pre-surgery), 3 months post-surgery, and 6 months post-surgery 4. CAL-at baseline (pre-surgery), 3 months post-surgery, and 6 months post-surgery—

Secondary

MeasureTime frame
Intra-oral periapical (IOPA) radiographsTimepoint: at baseline (pre-surgery), immediately after the surgery and at 6 months post-surgery—

Countries

India

Contacts

Public ContactDr Ruthali Vithal Kamat

Nair Hospital Dental College

maladixit25@gmail.com9223340938

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026