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Search of genetic markers predicting osteoporosis.

Can gene expression patterns in circulating precursors predict the development of osteoporosis and their correlation with bone turnover markers? A cohort based observational study.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/05/019364
Enrollment
400
Registered
2019-05-27
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E70-E88- Metabolic disorders

Interventions

None listed

Sponsors

ICMR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Premenopausal and postmenopausal (osteoporotic and nonosteoporotic)

Exclusion criteria

Exclusion criteria: All subjects having surgical menopause or having history of alcoholism, smoking, any steroid treatment or conditions that affect bone metabolism will not be included in the study.

Design outcomes

Primary

MeasureTime frame
To isolate PBMCs from premenopausal and postmenopausal women and to study the gene expression, miRNA and bone turnover markers.Timepoint: Data Collection - 2 and 1/2 years Data Analysis - 6 months—

Secondary

MeasureTime frame
To correlate the gene expression and also the bone mineral density based cohorts.Timepoint: Data Collection - 2 and 1/2 years Data Analysis - 6 months—

Countries

India

Contacts

Public ContactNirmal Raj Gopinathan

PGIMER

dr.nirmalraj78@gmail.com9914209740

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026