A study to compare the effectiveness and safety of different doses of a drug clonidine when used along with a drug bupivacaine in spinal anesthesia

A prospective randomized controlled trial to compare the efficacy and safety of different doses of clonidine when used as an adjuvant to intrathecal bupivacaine

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/05/019341

Enrollment

Registered

2019-05-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S729- Unspecified fracture of femur Health Condition 2: S929- Unspecified fracture of foot and toe Health Condition 3: S829- Unspecified fracture of lower leg

Interventions

Intervention1: Bupivacaine 0.5% heavy 2.5ml without clonidine in Spinal Anesthesia: Bupivacaine 0.5% heavy with clonidine in Spinal Anesthesia Control Intervention1: Bupivacaine 0.5% heavy 2.3 ml with

Eligibility

Inclusion criteria

Inclusion criteria: ASA I or II normotensive patients undergoing elective orthopaedic surgery

Exclusion criteria

Exclusion criteria: ASA III & above, patients with cardiovascular, renal, liver dysfunction, allergy to clonidine or bupivacaine, short height ( 30kg/m2) or with contraindication to spinal

Design outcomes

Primary

Measure	Time frame
Duration of analgesia/sensory block Block height Hemodynamic variations-pulse, MAP ComplicationsTimepoint: 1year	—

Secondary

Measure	Time frame
Hemodynamic effects-pulse and MAP ComplicationsTimepoint: 1 year	—

Countries

India

Contacts

Public ContactPrajwala S Kaushik

J J hospital

olesi_psk@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026