FindTrial
Sign In

comparison of hemodynamic stress response to endotracheal extubation post surgery with the combination of drugs Diltiazem-lignocaine, Esmolol-lignocaine and lignocaine alone- A prospective randamized control trial.

comparison of hemodynamic stress response to endotracheal extubation with the combination of Diltiazem-lignocaine, Esmolol-lignocaine and lignocaine alone- A prospective randamized control trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/05/019324
Enrollment
30
Registered
2019-05-24
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C439- Malignant melanoma of skin, unspecified Health Condition 2: C509- Malignant neoplasm of breast of unspecified site Health Condition 3: C759- Malignant neoplasm of endocrine gland, unspecified Health Condition 4: C579- Malignant neoplasm of female genital organ, unspecified Health Condition 5: C269- Malignant neoplasm of ill-definedsites within the digestive system Health Condition 6: C639- Malignant neoplasm of male genitalorgan, unspecified Health Condition 7: C409- Ma

Interventions

Control Intervention1: lignocaine 1mg/kg iv: 2minutes before extubation single dose

Sponsors

ShruthiN S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: patients belonging to ASA physical status 1 and 2 patients consenting for study

Exclusion criteria

Exclusion criteria: patient refusal patients belonging to ASA physical status 3 or more. any contraindication for the study drugs diltiazem, esmolol, lignocaine. pregnant and lactating woman. patients posted for emergency surgery

Design outcomes

Primary

MeasureTime frame
hemodynamic stress response to endotracheal extubationTimepoint: 2minutes before and at 0,1,2,3,5,10 minutes after endotracheal extubation—

Secondary

MeasureTime frame
complications like hypotension and bradycardia associated with the drug. airway reflexes like cough, laryngospasm, bronchospasm.Timepoint: 2minutes before and at 0,1,2,3,5,10 minutes after endotracheal extubation—

Countries

India

Contacts

Public ContactShruthi N S

kidwai memorial institute of oncology

arathibh@gmail.com9845285207

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026