Health Condition 1: B20- Human immunodeficiency virus [HIV]disease
Conditions
Interventions
Intervention1: Not applicable: Not applicable
Control Intervention1: Not applicable: Not applicable
Sponsors
Dr Ameet Dravid
Eligibility
Inclusion criteria
Inclusion criteria: 1) HIV-1 infected patients on antiretroviral therapy (ART) 2) Patients developing neurologic symptoms on ART 3) Patients found to have Neurosymptomatic CSF/Plasma HIV-1 RNA discordance (CSF HIV escape) defined as either a) detectable CSF HIV (CSF Viral Load more than 20 copies/ml) with an undetectable plasma HIV viral load (plasma viral load less than 20 copies/ml) or b) CSF HIV viral load 0.5 log10 higher than plasma HIV viral load
Exclusion criteria
Exclusion criteria: 1) Patients developing neurologic symptoms on antiretroviral therapy but not having CSF HIV escape.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Identification of distinct genetic profile of CNS HIV by Ultrasensitive deep sequencing which in turn better quantifies CNS HIV reservoir. 2) Identification of Macrophage tropic CNS HIV by cloning HIV envelope sequences by Pacbio sequel PCR 3) Identify any other virus which might help in enhancing HIV neurotoxicity 4) Identification of clinically significant biomarkers which cause immune activation in CNS and whose control might help in curtailing CNS reservoir. Timepoint: 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicableTimepoint: Not applicable | — |
Countries
India, Italy, Sweden, United States of America
Contacts
Public ContactAmeet Nandkumar Dravid
Poona Hospital and Research Centre
Outcome results
None listed