Comparison of pain reief with two different doses of the drug dexmedetomidine used in nerve block following one sided knee replacement surgery.

Comparison of different doses of dexmedetomidine as an adjuvant to ropivacaine in adductor canal block for post-operative analgesia following unilateral total knee replacement surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/05/019307

Enrollment

Registered

2019-05-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M171- Unilateral primary osteoarthritisof knee

Interventions

Intervention1: Addcutor Canal Block: Comparing different doses of dexmedetomidine ( 0.5mcg/kg and 1mcg/kg ) added to 0.2% ropivacaine Control Intervention1: NIL: NIL

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patient aged 18-85 years 2.ASA I , II & III

Exclusion criteria

Exclusion criteria: 1)Patients refusal 2)Allergic to local anaesthetic 3)Patient on B Blockers and a agonist 4)Previously operated knee surgery

Design outcomes

Primary

Measure	Time frame
To compare the analgesic efficacy of dexmedetomidine 0.5mcg/kg versus 1mcg/kg as an adjuvant to 0.2% ropivacaine in adductor canal block in patients undergoing unilateral total knee replacement surgeryTimepoint: Pain Score Post-operatively every 30 min for 2 hours and 4th hourly for 24 hours	—

Secondary

Measure	Time frame
1)To assess the duration of analgesia. 2)To compare motor blockade postoperatively. 3)Postoperative sedation score. 4)24 hour rescue analgesic consumption Timepoint: Postoperatively 30min for 2 hours and 4th hourly for 24 hours	—

Countries

India

Contacts

Public ContactDr Naveen Karthik M

Amrita Institute of Medical sciences

gokuldas75@hotmail.com9847448005

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026