Health Condition 1: N319- Neuromuscular dysfunction of bladder, unspecified
Conditions
Interventions
Intervention1: Treatment with bethanechol or alpha blocker or placebo: Patients meeting the inclusion criteria will be given either bethanechol or alpha blocker or placebo for 1 month duration after d
Sponsors
unsponsored
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age above 18 years 2. Urodynamic findings Male: BCI < 100, Qmax < 12 ml/sec 3. Patients should not already be taking any of the drugs under evaluation in the study , either alone or in combination
Exclusion criteria
Exclusion criteria: 1. Those who are not consenting to be a part of the study 2. Patients with complete spinal cord injury / lesions 3. Those with cardiac, cerebrovascular, hepatic impairment 4. Patients already on medications likely to interfere with the drugs under evaluation, i.e anticholinergics, alpha antagonists. 5. Patients with a known cause for bladder outlet obstruction such as stricture urethra, urethral polyp etc (except BPH) 6. Those patients in whom use of alpha blockers and cholinergics is contraindicated
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| assessing the change in detrusor pressure measured by pressure flow study by alpha blocker, bethanechol and placebo in male patients with detrusor underactivityTimepoint: After 1 month of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the efficacy between alpha blocker ,bethanechol and placebo treatment groups in improving IPSS score in patients with detrusor underactivity To assess the improvement in uroflometry and post void residual volume brought by use of above mentioned treatment groups in patients of detrusor underactivity. Timepoint: 1 month;To compare the efficacy between alpha blocker ,bethanechol and placebo treatment groups in improving IPSS score in patients with detrusor underactivity To assess the improvement in uroflometry and post void residual volume brought by use of above mentioned treatment groups in patients of detrusor underactivity. Timepoint: 1 month | — |
Countries
India
Contacts
Public ContactAditya Prakash Sharma
PGIMER
Outcome results
None listed