None listed
Conditions
Interventions
Intervention1: Maintenance of anaesthesia with intravenous infusion of propofol(Group P): After a detailed pre-anaesthetic evaluation, including preoperative cognitive assessment, general anaesthesia
Sponsors
Maulana Azad Medical College
Eligibility
Inclusion criteria
Inclusion criteria: Patients of American Society of Anaesthesiologists (ASA) physical status grades I/II/II requiring surgeries with expected duration of anaesthesia > 2hours
Exclusion criteria
Exclusion criteria: Patients unable to comprehend the required cognitive assessment tests Hindi Mental State Examination score less than or equal to 26 preoperatively Known cases of any psychiatric illness History of cerebrovascular accident Known disorder affecting cognition Known history of alcohol or drug abuse Deranged kidney function tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Postoperative Cognitive Dysfunction as assessed by Hindi Mental State Examination, Digit Span test and Digit Symbol Substitution Test, when there is at least 20% change from baseline values in at least 2 of these tests.Timepoint: 24 hours postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients showing at least 20% change from baseline values in individual assessment testsTimepoint: 24 hours postoperatively;Sensitivity of the three tests in detecting POCDTimepoint: 24 hours postoperatively | — |
Countries
India
Contacts
Public ContactDr Neetha Prabhu
Maulana Azad Medical College
Outcome results
None listed