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To find out the safest effective dose of oxytocin in non labouring pregnant patients

ED90 of Prophylactic Oxytocin Infusion During Cesarean Delivery in Non-laboring Preeclamptics receiving Magnesium Sulfate Therapy versus Normotensives: An Up-Down Sequential Allocation Dose-Response Study - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/05/019268
Enrollment
80
Registered
2019-05-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O754- Other complications of obstetric surgery and procedures

Interventions

Intervention1: Oxytocin Infusion: Oxytocin Infusion will be initiated by intravenous route, at dose of 18U/hour in first patient, with dosing interval of 2U/hour, continued from cord clamping to end o

Sponsors

University College of Medical Sciences and GTB Hospiytal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All non-laboring parturient , whether preeclamptics who are receiving magnesium sulfate therapy or normotensives without magnesium sulfate therapy, posted for elective cesarean section under spinal anesthesia will be enrolled.

Exclusion criteria

Exclusion criteria: Exclusion criteria will include patient refusal, need for general anesthesia, presence of labor (defined as cervical dilatation of 3 cm or more), history of PPH or more than one previous uterine surgery as well as bleeding disorders, and presence of abnormal placentation and uterine fibroid. Those with any contraindication to spinal block such as hemodynamic instability, infection at site of injection, coagulopathy (thrombocytopenia with platelet count <100,000/mm3) etc. will also be excluded

Design outcomes

Primary

MeasureTime frame
The calculated ED90 of prophylactic oxytocin infusion in both cohorts.Timepoint: The infusion will be continued from cord-clamping to end of surgery.

Secondary

MeasureTime frame
NilTimepoint: Nil

Countries

India

Contacts

Public ContactDr Devansh Garg

University College of Medical Sciences and GTB Hospital

drashatyagi@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026