Health Condition 1: E200- Idiopathic hypoparathyroidism
Conditions
Interventions
Intervention1: Calcitriol: Route of adminstration: oral
Dose: calcitriol dose would be half of the the dose of alfacalcidol (Weight /weight) on which patient is already maintaining calcemic control.
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: All the patients with idiopathic hypoparathyroidism who are willing to participate and come for regular follow up for at least three months from the date of achieving ideal control serum calcium level between 8.0-9.5 mg/dl
Exclusion criteria
Exclusion criteria: Suboptimal calcium control with serum calcium less than 8.0 mg/dl, History of poor compliance with follow up and or drugs in the previous trials Not willing to visit at the designated interval of every 15 days during adjustment of therapy history of any other active illness or hypocalcemic seizures during last six months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ability to achieve ideal control as indicated by serum calcium between 8.0-9.5, serum phosphate less than 4.5 mg/dl and urine calcium creatinine excretion ratio not more than 0.20 mg/mg in two study armsTimepoint: 12 weeks after the stable serum calcium is achieved on calcitriol and alphacalcidol groups | — |
Secondary
| Measure | Time frame |
|---|---|
| Determination of equivalence dose of calcitriol and alfacalcidol for optimal calcium control in idiopathic hypoparathroidismTimepoint: three months;Differences in the serum FGF23 and 1,25 dihdroxy vitamin D levels at attainemnet of optical calcium control in the two study armsTimepoint: Three months | — |
Countries
India
Contacts
Public ContactSoma Saha
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed