Comparative study to modify harmful blood pressure and heart rate changes during placement of a tube inside windpipe for securing airway with dexmedetomidine and esmolol

Comparative study of hemodynamic responses during laryngoscopy and endotracheal intubation with dexmedetomidine and esmolol

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/05/019172

Enrollment

Registered

2019-05-16

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: I978- Other intraoperative and postprocedural complications and disorders of the circulatory system, not elsewhere classified

Interventions

Intervention1: esmolol 0.75 mg/kg: Group E patients will receive IV bolus of esmolol 0.75 mg/kg diluted in 20 ml with normal saline given 2 min before intubation. Control Intervention1: dexmedetomidin

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and ASA 2

Exclusion criteria

Exclusion criteria: patients with ischemic heart disease, hypertension, Diabetes mellitus, pregnant, anticipated difficult airway, duration of laryngoscopy more than 20 seconds

Design outcomes

Primary

Measure	Time frame
To compare the clinical effects of dexmedetomidine and esmolol SBP,DBP,MAP,Heart rate,SpO2 recording Timepoint: SBP,DBP,MAP,Heart rate,SpO2 recording At baseline At 60 sec after infusion of dexmedetomidine/ esmolol Immediately after induction At 1 min after intubation At 3 min after intubation At 5 min after intubation At 10 min after intubation	—

Secondary

Measure	Time frame
Attenuation of hemodynamic responses during laryngoscopy and endotracheal intubation.Timepoint: SBP,DBP,MAP,Heart rate,SpO2 recording At baseline at 60 sec after infusion of dexmedetomidine/ esmolol Immediately after induction At 1 min after intubation At 3 min after intubation At 5 min after intubation At 10 min after intubation	—

Countries

India

Contacts

Public ContactVishwanath R Hiremath

Sri Manakula Vinayagar Medical College and Hospita

vishwanath0506@gmail.com9442934258

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026