Skip to content

Clinical Trial to compare the effectiveness of Chlorhexidine at lower concentrations for Pneumonia development in ventilator assisted patients

Effectiveness of oral hygiene with Chlorhexidine mouth wash with different concentration (0.12% and 0.2%) on incidence of VAP; - A Prospective Comparative Randomized Controlled Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/05/019116
Enrollment
140
Registered
2019-05-14
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J13- Pneumonia due to Streptococcus pneumoniae

Interventions

Intervention1: Chlorhexidine mouth wash 0.12% : Chlorhexidine 0.12% will be prepared by diluting 0.2% chlorhexidine (6 ml 0.2% chlorhexidine + 40ml sterile water) Available brand - Hexiclear Mout

Sponsors

Dr Nagesh Vyas
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Male or female patients of age 18 to 75 yrs, 2. Requiring mechanical ventilation for at least more than 72 hours with normal hemodynamics with or without vasopressor

Exclusion criteria

Exclusion criteria: 1. Known case pneumonia 2. Development of pneumonia within 48 hours of intubation 3. Chronic Obstructive Lung Disease with active chest infection; patients 4. Patients already received mechanical ventilation for more than 24 hours 5. Patients who have aspirated/with chest x-rays already showing infiltrates 6. Oral mucositis: It may cause local irritation and hypersensitivity. 7. Legal incarceration (e.g., organ transplantation or patients having long-term steroid therapy): They have a chance of hypersensitivity reaction. 8. Patients who died or were discharged within 48 hours of admission in the ICU. 9. Patients receiving immunosuppressive therapy or who were hypersensitive to chlorhexidine gluconate

Design outcomes

Primary

MeasureTime frame
Incidence of Ventilator associated Pneumonia diagnosed by Endotracheal Secretion culture for P-pneumoniaTimepoint: Every 48 hrs after intubation for incidence of VAP

Secondary

MeasureTime frame
DeathTimepoint: Everyday with 3 hour shit, check for vitals;DeintubationTimepoint: Everyday a through clinical examination and check of lab value for deintubation;Discharge from ICUTimepoint: Everyday when patient is deintubated and discharged from ICU

Countries

India

Contacts

Public ContactDr Nagesh Vyas

Apex Hospital

priyamathur2753855@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026