Health Condition 1: null- Schizophrenia with negative symptoms of PANSS equal or more than 15
Conditions
Interventions
Intervention1: rTMS: repetitive transcarnial magnetic stimulation. Will be used to treat randomized arms. Active arm will receive Real rTMS and control arm will receive Sham rTMS
Control Intervention1
Sponsors
DEPARTMENT OF SCIENCE AND TECHNOLOGY
Eligibility
Inclusion criteria
Inclusion criteria: Schizophrenia having PANSS negative symptoms with score of 15 or more. Willing to participate in the study Should be able to meet ICD10 criteria
Exclusion criteria
Exclusion criteria: 1.Individuals diagnosed by the investigator with the following conditions (current unless otherwise stated): Comorbid ICD-10 Axis I diagnosis, particularly current affective disorder including Depressive Disorder, Bipolar Affective Disorder; substance abuse or dependence within the past year (except nicotine and caffeine)as assessed on M.I.N.I. History of seizure, TIA, dementia, pregnancy, any movement disorder, metallic implant within or near the head, history of rTMS intervention, implanted medicated pumps,any cardiac illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive symptoms improvement in: immediate & delayed memory -auditory and visual perceptual motor and executive functioning Verbal N Back test Negative symptoms assessment changes Timepoint: Baseline, 20th day post rTMS, 30th day post rtms(1month) | — |
Secondary
| Measure | Time frame |
|---|---|
| Global clinical improvement on Clinical global impression Depression as on the Calgary depression scale for schizophrenia. Assessment of above parameters at 1 month follow up to assess whether the effects last longer. Timepoint: Baseline, 20th day post rTMS, 30th day post rtms(1month) | — |
Countries
India
Contacts
Public ContactDr Nand Kumar
ALL INDIA INSTITUTE OF MEDICAL SCIENCES
Outcome results
None listed