Health Condition 1: I958- Other hypotension
Conditions
Interventions
Intervention1: Norepinephrine: Norepinephrine infusion will be started at 0.05 microgram/kg/minute in children requiring vasoactive agents and increased at 15 minute intervals till target BP is achiev
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 2 months to 17 years with early septic shock, defined as children with suspect or confirmed sepsis and unresolved shock/hypoperfusion after the initial 20ml/kg fluid bolus.
Exclusion criteria
Exclusion criteria: 1. Children with fulminant myocarditis 2. Children with unrepaired congenital heart disease 3. Post-operative sepsis/septic shock within 72 hours of bypass surgery. 4. Children with Severe Acute Malnutrition 5. Children with chronic kidney disease. 6. Parents not willing to participate in the study 7. Caregiver/Physician unwilling for patient to be enrolled 8. Post-arrest shock and cardiac dysfunction 9. Moribund patients in whom anticipated survival
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fluid volume in ml/kg required in first 6 hours of beginning vasoactive agentsTimepoint: At 6 hours of enrollment | — |
Secondary
| Measure | Time frame |
|---|---|
| MoratlityTimepoint: Measured till 28 days from the time of admission. Measured at 28 days or earlier if death occurs.;Organ dysfunction scoresTimepoint: At 24, 48 and 72 hours;Proportion of children achieving shock resolutionTimepoint: Measured at 6,12, 24, 48 and 72 hours of resuscitation | — |
Countries
India
Contacts
Public ContactJhuma Sankar
All India Institute of Medical Sciences
Outcome results
None listed