Health Condition 1: K859- Acute pancreatitis, unspecified
Conditions
Interventions
Intervention1: Non Invasive Ventilation: Participants randomised to intervention group will receive NIV via appropriate size face mask or helmet as preferred by the patient in bilevel positive airway
Sponsors
All India Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Acute pancreatitis as defined by revised Atlanta classification.1 2. Hospitalisation within 14 days of date of onset of pain. 3. Grade II/III respiratory failure as defined by modified Marshallâ??s criteria.
Exclusion criteria
Exclusion criteria: 1. Age 70 years 2. Pregnancy 3. Failure to give consent 4. Undrained large pleural effusion 5. Previous mechanical ventilation in last 7 days 6. Contraindications to NIV use: a. Glasgow coma scale b. Airway/facial injury. c. Hypotension requiring inotropes. d. Intractable vomiting. e. Active gastrointestinal bleeding. f. Untreated paralytic ileus. g. Untreated pneumothorax. h. Acute myocardial infarction/arythmmia/congestive heart failure. 7. Underlying chronic obstructive airway disease(COPD). 8. Renal failure requiring dialysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Need for invasive mechanical ventilation 2. Hospital acquired pneumoniaTimepoint: within 30 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. mortality within 30 days 2. Duration of ICU stay 3. Duration of hospital stay 4. Incidence, severity and impact on outcome of acute respiratory failure in patients with acute pancreatitisTimepoint: within 30 days | — |
Countries
India
Contacts
Public ContactProf Pramod Garg
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed