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Role of Lycium barbarum mouthwash in treating gum diseases

Clinical and antimicrobial efficacy of Lycium barbarum mouthwash compared to 0.2% chlorhexidine gluconate mouthwash as an adjunct to periodontal debridement for the management of mild to moderate chronic periodontitis: A double-blind randomized control clinical trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/05/019042
Enrollment
90
Registered
2019-05-10
Start date
Unknown
Completion date
Unknown
Last updated
2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B968- Other specified bacterial agents as the cause of diseases classified elsewhere

Interventions

Intervention1: Mouthwash containing Extract from Lycium barabrum: All patients in the intervention group will be given complete oral prophylaxis followed by which they will given mouthwash containing

Sponsors

Manipal College of Dental Sciences Manipal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Ninety systemically healthy subjects aged 20 to 50 years male/female will be screened for the presence of mild to moderate chronic generalized periodontitis (clinical attachment loss of = 5mm in more than 30% of present sites). 2. Chronic generalized periodontitis (CGP) according to AAP 1999 classification is defined as “clinical attachment loss 3. The clinical attachment loss of less than 5 mm without any probing depth will also be considered under mild to moderate periodontitis and will be included. The patient should have 24 4. functional teeth.

Exclusion criteria

Exclusion criteria: 1. Subjects with clinical attachment loss of more than 5mm (severe periodontitis) will be excluded in order to exclude patients with severe periodontitis. 2. Patient with systemic allergic to chlorhexidine 3. Subjects with any systemic diseases, any concurrent medications 4. Patient on high polyphenol and antioxidant diet 5. Pregnant or lactating mothers, or having habits detrimental to oral health, e.g. smoking, consuming alcohol, betel nut chewing or using any other form of tobacco, will be excluded from the study. 6. Patients who had undergone any periodontal treatment in the previous six months or those using any orthodontic appliances or dental prostheses 7. Subjects using any other oral hygiene agents for removing plaque and controlling gingival inflammation along with regular tooth brushing will be excluded to remove confounding bias arising due to the difference in plaque control measures.

Design outcomes

Primary

MeasureTime frame
Clinical parameters such as Full mouth - Gingival index, Plaque index, reduction in sites with bleeding on probing, pocket depth and clinical attachment levelTimepoint: 0, 2 weeks, one month and three months

Secondary

MeasureTime frame
Secondary outcomes: Microbial count of the bacteria along with the changes in antioxidant capacity of saliva.Timepoint: 0, 2 weeks,one month and 3 months

Countries

India

Contacts

Public ContactDr Aditi Chopra

Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal

draditichopra@gmail.com919739863908

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026