Health Condition 1: A90- Dengue fever [classical dengue]
Conditions
Interventions
None listed
Sponsors
Manipal Institute of Virology
Eligibility
Inclusion criteria
Inclusion criteria: Acute febrile illness (AFI) cases (within 72 hrs of onset of fever) with any other symptoms suggestive of dengue fever, like headache, bodyache, retro-orbital pain, nausea/vomiting, petechiae/ecchymoses/purpura, bleeding gums, rash, abdominal pain, lethargy/restlessness, admitted in ICUs as well as wards at KMC, Manipal
Exclusion criteria
Exclusion criteria: Not willing to provide informed consent and without a legally authorized representative available Immuno-compromised cases like HIV+ve (with CD4 count Known cases of Liver cirrhosis Mixed infections (malaria, influenza, chikungunya, scrub typhus, leptospirosis, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insight into association of DENV NS1 antigenemia & viremia with disease severity â?¢ Effect of serotype-specific DENV NS1 on capillary permeability in mouse model Timepoint: one year, two year, three year | — |
Secondary
| Measure | Time frame |
|---|---|
| Role of DENV NS1-anti NS1 immune complex formation in disease pathogenesis and its association with disease severityTimepoint: one year two years three years | — |
Countries
India
Contacts
Public ContactDr Puneet Bhatt
Manipal Academy of Higher Education
Outcome results
None listed