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Effects of NAVA on diaphragm function

Effects of NAVA and conventional modes of mechanical ventilation on diaphragm functions: A Randomized Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/05/019018
Enrollment
70
Registered
2019-05-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J471- Bronchiectasis with (acute) exacerbation Health Condition 2: J441- Chronic obstructive pulmonary disease with (acute) exacerbation Health Condition 3: J439- Emphysema, unspecified Health Condition 4: J459- Other and unspecified asthma Health Condition 5: J848- Other specified interstitial pulmonary diseases Health Condition 6: J42- Unspecified chronic bronchitis

Interventions

Intervention1: NAVA Mode of Ventilation: NAVA Catheter will be placed and patient will be ventilated with NAVA mode of Ventilation and Daily Diaphragm Function will be Assessed by Ultrasonography Cont

Sponsors

Department of Pulmonary Critical Care and Sleep Medicine
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. All adult patient (age more than or equal to 18 years) presenting with respiratory failure requiring invasive mechanical ventilation. 2. Patients able to spontaneously trigger the ventilator

Exclusion criteria

Exclusion criteria: 1. Unable to trigger ventilator 2. Moderate or severe acute respiratory distress syndrome (ARDS) 3. Presence of three or more organ system failures 4. Neurological or neuromuscular disease(CVA,GBS,Mysthaeniaetc) 5. Known Phrenic nerve palsy 6. Patient who cannot be ventilated without neuromuscular blockers 7. Patient in shock requiring 2 or more inotropes 8. Any contraindication to the insertion of a nasogastric tube (for example: recent upper gastrointestinal surgery, esophageal varices). 9. Patients on mechanical ventilation for more than 3 days. 10. Patient not willing to participate

Design outcomes

Primary

MeasureTime frame
To compare the incidence of diaphragmatic dysfunction (defined as diaphragm thickness fraction less than 20%) in patient ventilated with NAVA as compared to conventional mechanical ventilation.Timepoint: Day 5 or Day of Extubation whichever is earlier—

Secondary

MeasureTime frame
1. Change in thickness of Diaphragm 2. Diaphragmatic excursion 3. Diaphragmatic efficiency (NVE and NME) Timepoint: Day 5 or Day of Extubation which ever is earlier—

Countries

India

Contacts

Public ContactSourabh Pahuja

AIIMS

vijayhadda@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026