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Comparison of the seizure drug levetiracetam with controlled release carbamazepine in new focal seizure patients

A comparative study of the safety, efficacy, quality of life outcome and pharmacoeconomics of levetiracetam with controlled-release carbamazepine in patients of new onset focal seizures

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/05/018990
Enrollment
60
Registered
2019-05-08
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G400- Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset Health Condition 2: G402- Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures Health Condition 3: G401- Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures

Interventions

Intervention1: Levetiracetam: Levetiracetam 500 mg twice daily and titrated upto 3000 mg per day depending upon seizure control. Duration of the treatment will depend upon the clinical outcome as per
this carbamyl moiety provides potent anti-seizure activity. Carbamazepine is also a mood stabilizer and is used to treat bipolar disorder. Carbamazepine is a prototypical sodium channel-blocking anti-

Sponsors

Institutional sponsored
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: The study will include all the newly diagnosed consenting adult patients of focal seizures without any other co-morbidities

Exclusion criteria

Exclusion criteria: Patients not willing to give written informed consent. Pregnant females. Patients already on treatment with study drugs. Patients of seizures others than focal seizures. Patients of head trauma within past one month. Patients with known contraindication or refractoriness to study drugs.

Design outcomes

Primary

MeasureTime frame
Minimal adverse drug reactions and seizure freedomTimepoint: At 1 month, 3 months and 6 months

Secondary

MeasureTime frame
PharmacoeconomicsTimepoint: At 6 months;Quality of life outcomeTimepoint: Before initiating treatment and at 6 months

Countries

India

Contacts

Public ContactDr Nitin Patiyal

Dr. R.P.G.M.C, Kangra at Tanda

dinesh.kansal56@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026