Use of high definition transcranial direct current stimulation in negative symptoms of Schizophrenia and changes in proton magnetic resonance spectroscopic findings

Efficacy of high definition transcranial direct current stimulation in negative symptoms of Schizophrenia as measured by proton magnetic resonance spectroscopy - a randomised sham controlled study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/05/018947

Enrollment

Registered

2019-05-06

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F203- Undifferentiated schizophrenia

Interventions

Intervention1: High Definition transcranial Direct Current Stimulation Active: The central active anode electrode will be placed over the left dorsolateral prefrontal cortex which will be surrounded b

Eligibility

Inclusion criteria

Inclusion criteria: 1. Diagnosis of Schizophrenia using Diagnostic Criteria for Research (DCR) of International Classification of Disease-10th edition (ICD-10, World Health Organization,1992) 2. Age between 18- 60 years of either sex 3. The Positive and Negative Syndrome Scale for Schizophrenia (PANSS) negative symptoms score of more than 15 4. Scale for Assessment of Negative Symptoms (SANS) score more than 20 5. Calgary Depression Scale for Schizophrenia (CDSS) score less than 7 6. Right handed 7. Patients giving written informed consent.

Exclusion criteria

Exclusion criteria: 1. Presence of co-morbid neurological or other psychiatric disorder(s). 2. Patient with co morbid substance dependence, except nicotine and caffeine. 3. Having any metallic implants/parts in body 4. Subjects who have received Electroconvulsive therapy in past 6 months.

Design outcomes

Primary

Measure	Time frame
Primary outcome of the study is change in negative symptoms score as assessed at the end of 2 weeks of HDtDCS treatment with the specially designed score sheet.Timepoint: PANSS, SANS, CGI, CDSS WILL BE APPLIED AT THE END OF 2 WEEKS & 6WEEKS	—

Secondary

Measure	Time frame
Secondary outcomes are changes in the levels of GABA, Glutamate, Glutamine, N-Acetyl Aspartate & N-Acetyl Aspartyl Glutamate in Dorsolateral Prefrontal Cortex using Proton MR Spectroscopic imaging and overall severity scores on CGI.Timepoint: Proton Magnetic Resonance Spectroscopy will be done before giving HD tDCS and after 2 sessions of HD tDCS and at the end of 2 weeks.	—

Countries

India

Contacts

Public ContactDr Nishant Goyal

Central institute of psychiatry

psynishant@gmail.com9431171162

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026