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To compare the effect of the drugs, midazolam (in low dose) and midazolam with fentanyl, on muscle movement caused by another drug, etomidate, when it is used for giving anaesthesia before surgery.

Comparison of pretreatment with low dose midazolam and fentanyl with midazolam alone on occurrence of etomidate induced myoclonus in patients for surgery under general anesthesia

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/05/018920
Enrollment
60
Registered
2019-05-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Y658- Other specified misadventures during surgical and medical care

Interventions

Intervention1: low dose midazolam and fentanyl: low dose midazolam and fentanyl will be given before administration of etomidate Control Intervention1: midazolam: midazolam will be given before admini

Sponsors

Department of Anesthesiology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiology physical status I and II adult patients undergoing elective surgical procedures under general anaesthesia

Exclusion criteria

Exclusion criteria: Patients with 1. History of any neurological disease 2. Adrenal cortical dysfunction 3. History of allergy to study drugs 4. Those having received any sedative within previous 24 hours 5. Pregnant or lactating women

Design outcomes

Primary

MeasureTime frame
Occurrence of myoclonic movements after etomidate injection.Timepoint: Upto 90 seconds after etomidate injection—

Secondary

MeasureTime frame
To study the effect of pretreatment with low dose midazolam with fentanyl and midazolam alone on heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and oxygen saturationTimepoint: After test drug administration and then every minute for 5 minutes—

Countries

India

Contacts

Public ContactDr Khaise Hareed

P.G.I.M.E.R. & Dr. RML Hospital

nishakachru@yahoo.co.uk9810488435

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 14, 2026