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Comparison of effect of combination of Ketamine and Propofol versus Propofol alone on Jugular Venous Oxygen Saturation in moderate to severe traumatic brain injury.

Comparison of effect of Ketofol(Ketamine and Propofol) versus Propofol on jugular venous oxygen saturation in moderate to severe traumatic brain injury:a prospective randomized trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/04/018857
Enrollment
40
Registered
2019-04-30
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: -

Interventions

Intervention1: Ketofol( combination of Ketamine and Propofol in the ratio 1:5): Ketofol infusion ( 1 ml of study drug contains 8.33 mg of Propofol and 1.67 mg of Ketamine) used as maintenance agent fo

Sponsors

Department of anesthesia and intensive care PGIMER Chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I/ IIE, with moderate to severe traumatic brain injury planned for decompressive craniectomy

Exclusion criteria

Exclusion criteria: patients with known psychiatric or neurodegenerative disease extradural hematomas pregnant females allergy to any of the study drugs

Design outcomes

Primary

MeasureTime frame
monitoring cerebral oxygenation by jugular venous oxygen saturation(SJVO2)Timepoint: baseline, at 1 hour and 2 hours of drug infusion, at 6 hours after end of drug infusion—

Secondary

MeasureTime frame
Glasgow Outcome scale Extended(GOSE)Timepoint: at 1 and 3 months;hemodynamic parametersTimepoint: intraoperative and postoperative;Modified Rankins scale( MRS)Timepoint: at discharge;optic nerve sheath diameter (ONSD)Timepoint: Preoperative and postoperative;quality of brain relaxationTimepoint: intraoperative;S100B levelsTimepoint: preoperative , postoperative and 48 hours after surgery—

Countries

India

Contacts

Public ContactDr Nidhi B Panda

PGIMER, CHANDIGARH

tsjasial@gmail.com8968677948

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026