A study to compare efficacy of two drugs( Pregabalin and Clonidine)when given orally to make endotracheal intubation during general anaesthesia safer.

A comparative study of efficacy of oral Pregabalin and Clonidine for attenuation of pressor response to intubation

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/04/018837

Enrollment

100

Registered

2019-04-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K80- Cholelithiasis Health Condition 2: C50- Malignant neoplasm of breast Health Condition 3: 8- Other Procedures

Interventions

Intervention1: Pregabalin: To evaluate the efficacy of oral Pregabalin 150mg for attenuation of haemodynamic response to laryngoscopy and tracheal intubation. Control Intervention1: Clonidine: To eval

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients for elective surgery planned under general anaesthesia of American Society of Anaesthesiologists (ASA) Physical Status I & II 2) Age group 20-60 years of either gender, giving valid informed and written consent

Exclusion criteria

Exclusion criteria: 1) Patient refusal 2) Anticipated difficult airway 3) Morbid obesity 4) ASA Physical Status III and IV 5) Known case of hypertension 6) Drug allergy to any anaesthetic medication/study drugs 7) Pregnant patients 8) Patients on sedatives, hypnotics or sympatholytics

Design outcomes

Primary

Measure	Time frame
1) To evaluate the efficacy of oral Pregabalin 150mg for attenuation of haemodynamic response to laryngoscopy and tracheal intubation. 2) To evaluate the efficacy of oral Clonidine 200Âµg for attenuation of haemodynamic response to laryngoscopy and tracheal intubation. 3) To compare the efficacy of oral Pregabalin 150mg and oral Clonidine 200Âµg for attenuation of haemodynamic response to laryngoscopy and tracheal intubation. Timepoint: 1)Baseline(At time of premedication) (Tb) 2)30 minutes after premedication (T0.5) 3)60 minutes after premedication (T1) 4)90 minutes after premedication (Just before induction) (T1.5) 5)After induction (Just before intubation) (Ti) 6)Just after intubation (T0i) 7)1 minute after intubation (T1i) 8)2 minute after intubation (T2i) 9)3 minutes after intubation (T3i) 10)5 minutes after intubation (T5i) 11)8 minutes after intubation (T8i) 12)10 minutes after intubation (T10i)	—

Measure

Time frame

1) To evaluate the efficacy of oral Pregabalin 150mg for attenuation of haemodynamic response to laryngoscopy and tracheal intubation. 2) To evaluate the efficacy of oral Clonidine 200Âµg for attenuation of haemodynamic response to laryngoscopy and tracheal intubation. 3) To compare the efficacy of oral Pregabalin 150mg and oral Clonidine 200Âµg for attenuation of haemodynamic response to laryngoscopy and tracheal intubation. Timepoint: 1)Baseline(At time of premedication) (Tb) 2)30 minutes after premedication (T0.5) 3)60 minutes after premedication (T1) 4)90 minutes after premedication (Just before induction) (T1.5) 5)After induction (Just before intubation) (Ti) 6)Just after intubation (T0i) 7)1 minute after intubation (T1i) 8)2 minute after intubation (T2i) 9)3 minutes after intubation (T3i) 10)5 minutes after intubation (T5i) 11)8 minutes after intubation (T8i) 12)10 minutes after intubation (T10i)

—

Secondary

Measure	Time frame
To assess and compare preoperative sedation and anxiety with the use of oral Pregabalin 150mg and oral Clonidine 200Âµg.Timepoint: 1)Baseline 2)30 minutes 3)60 minutes 4)90 minutes	—

Countries

India

Contacts

Public ContactJatin Gupta

Baba Farid University of Health Sciences,Faridkot,Punjab

drbaghla@yahoo.com9814035236

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026