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Use of Advanced Magnetic Resonance Imaging (MRI)- a neuroimaging modality- for predicting functional outcome in severe traumatic brain injury

Advanced Magnetic Resonance Imaging (MRI) based predictors of long term functional outcome in severe traumatic brain injury

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2019/04/018800
Enrollment
70
Registered
2019-04-26
Start date
Unknown
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S060- Concussion Health Condition 2: S064- Epidural hemorrhage Health Condition 3: S063- Focal traumatic brain injury Health Condition 4: S068- Other specified intracranial injuries Health Condition 5: S061- Traumatic cerebral edema Health Condition 6: S066- Traumatic subarachnoid hemorrhage Health Condition 7: S065- Traumatic subdural hemorrhage Health Condition 8: S069- Unspecified intracranial injury

Interventions

None listed

Sponsors

NIMHANS intramural funding
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Severe TBI patients (GCS 2) GCS 4) Isolated TBI

Exclusion criteria

Exclusion criteria: 1) Penetrating head injury 2) Associated extra-cranial injury 3) Patients who are hemodynamically unstable and requiring inotropic or vasoactive drugs 4) Patients on sedative infusions (thiopental sodium/propofol/midazolam) 5) Pregnant patients 6)Prior history of neurological or mental health disorders or patients on chronic medication 7)Patients with contraindications for MRI like pacemaker, metal implants or eye injury 8) Refusal of consent by patient’s care taker

Design outcomes

Primary

MeasureTime frame
1) Whether EEG-fMRI, DTI and MRS done at 4-7 days after severe head injury are able to predict favorable (GOS 4-5) and unfavorable (GOS1-3) outcomes at 6 months and 1 year after injury 2) Compare outcomes predicted by MR imaging tools with outcomes predicted by existing prognostication models (CRASH and IMPACT) Timepoint: 4-7 DAYS of ICU admission 1st MRI and Followup MRI at 3-6 months—

Secondary

MeasureTime frame
1) Whether EEG-fMRI, DTI and MRS done at 4-7 days after severe head injury are able to predict favorable (GOS 4-5) and unfavorable (GOS1-3) outcomes at 6 months and 1 year after injury 2) Compare outcomes predicted by MR imaging tools with outcomes predicted by existing prognostication models (CRASH and IMPACT) Timepoint: 4-7 DAYS of ICU admission 1st MRI and Followup MRI at 3-6 months—

Countries

India

Contacts

Public ContactRohini M Surve

NIMHANS, Bengaluru

rohinigondhule@gmail.com9480829840

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026