FindTrial
Sign In

Which is better in management of increased intra cranial pressure among children, hypertonic (3%) saline (NaCl) or mannitol? An Experimental Study

Hypertonic Saline Vs Mannitol in The Management of Raised Intracranial Pressure: A Single Blind Randomised Control Trial - ICP TRIAL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/04/018788
Enrollment
220
Registered
2019-04-25
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G934- Other and unspecified encephalopathy

Interventions

Intervention1: HYPERTONIC SALINE (3% NaCl): LOADING @ 5 ML / KG FOLLOWED BY MAINTAINANCE @ 3ML /KG 8 HOURLY FOR FIRST 72 HOURS OF HOSPITALIZATION Control Intervention1: MANNITOL: LOADING @ 5 ML / KG F

Sponsors

Veer Surendra Sai Institute of Medical Sciences and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Children admitted to our hospital with clinical symptoms and signs suggestive of raised intracranial pressure

Exclusion criteria

Exclusion criteria: Children with 1.Compromised renal function 2.Hepatic encephalopathy 3.Serum Na+ (.150meq/L) 4.Diabetic ketoacidosis 5.Cerebral malaria 6.Low blood pressure as per the age

Design outcomes

Primary

MeasureTime frame
To find out the efficacy of hypertonic saline vs mannitol in decreasing mean arterial pressureTimepoint: AT 0 HOUR, 24 HOUR, 72 HOUR—

Secondary

MeasureTime frame
1. To find out the incidence of electrolyte imbalance (Na, K) between two groups 2.To find out the morbidity and mortality between two groupsTimepoint: 1. Estimation of serum Na and serum K at 0, 24, 72 hour of hospitalisation 2. Duration of hospitalisation in days till discharge or death from hospital—

Countries

India

Contacts

Public ContactPRAKASH CHANDRA PANDA

VEER SURENDRA SAI INSTITUTE OF MEDICAL SCIENCES AND RESEARCH (VIMSAR)

drnihar.mishra@gmail.com9337797072

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026