Comparison of clindamycin - benzoyl peroxide versus adapalene - benzoyl peroxide in patients of acne

Comparative study of efficacy, safety and cost effectiveness of topical combination therapy with clindamycin 1% - benzoyl peroxide 2.5% versus adapalene 0.1% - benzoyl peroxide 2.5% in cases of mild to moderate facial acne vulgaris: A prospective, randomized, open label, parallel study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/04/018786

Enrollment

Registered

2019-04-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L700- Acne vulgaris

Interventions

Intervention1: clindamycin 1% cream and benzoyl peroxide 2.5 % cream: Clindamycin is a lincosamide antibiotic having antibacterial and anti-inflammatory properties.it inhibits the bacterial protein sy

Eligibility

Inclusion criteria

Inclusion criteria: 1) Subjects of either gender 2) Subjects of 12 to 35 years of age with mild to moderate (comedones, papules and few pustules) facial acne vulgaris having more than or equal to 2 and less than equal to 30 lesions(inflammatory and/or non inflammatory) lesions

Exclusion criteria

Exclusion criteria: 1)Patients already on anti-acne medication in last one month 2) Patients having nodulocystic lesions, acne conglobata, acne fulminans, secondary acne 3) Patients unwilling to give written informed consent 4) Patients with known hypersensitivity to benzoyl peroxide, clindamycin or adapalene 5) Pregnant or lactating women

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of clindamycin 1% -benzoyl peroxide 2.5% with adapalene 0.1% - benzoyl peroxide 2.5% in mild to moderate facial acne vulgaris by lesion counting.Timepoint: 4 weeks, 8 weeks and 12 weeks	—

Secondary

Measure	Time frame
1)To compare the safety of clindamycin 1% -benzoyl peroxide 2.5% with adapalene 0.1% - benzoyl peroxide 2.5% in mild to moderate facial acne vulgaris by lesion counting by clinical examination on scale of 0 to 3. 2)To compare the cost effectiveness of clindamycin 1% -benzoyl peroxide 2.5% with adapalene 0.1% - benzoyl peroxide 2.5% in mild to moderate facial acne vulgaris by lesion counting.Timepoint: 4, 6 and 12 weeks	—

Measure

Time frame

1)To compare the safety of clindamycin 1% -benzoyl peroxide 2.5% with adapalene 0.1% - benzoyl peroxide 2.5% in mild to moderate facial acne vulgaris by lesion counting by clinical examination on scale of 0 to 3. 2)To compare the cost effectiveness of clindamycin 1% -benzoyl peroxide 2.5% with adapalene 0.1% - benzoyl peroxide 2.5% in mild to moderate facial acne vulgaris by lesion counting.Timepoint: 4, 6 and 12 weeks

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Countries

India

Contacts

Public ContactDr Jayesh Mukhi

Government medical college, Nagpur

gndakhle@rediffmail.com9850539353

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026