This is a study meant to observe the effect of two drugs, magnesium sulfate and dexmeditomidine, in reducing the requirement of other drugs used in general anesthesia.

Effect of magnesium sulfate and dexmeditomidine as adjuvants on requirement of anesthetic agents in total intravenous anesthesia-A randomised placebo controlled trial. - TIVA

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/04/018757

Enrollment

Registered

2019-04-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K819- Cholecystitis, unspecified

Interventions

Intervention1: 1.Dexmeditomidine 2.Magnesium sulfate: 1.Dexmeditomidine loading dose of 0.5mcg/kg in 100ml normal saline before induction over a period of 15mins and maintenance of 0.3mcg/kg/hr in a 2

Eligibility

Inclusion criteria

Inclusion criteria: 1. American society of anesthesiologists(ASA) physical status I and II 2. Scheduled for elective laparoscopic cholecystectomy(maximum duration 2hrs).

Exclusion criteria

Exclusion criteria: 1. Hepatic, renal,respiratory disorders. 2. Seizure disorder,endocrinal,hematological disorders. 3. Obesity(BMI >30) 4. Prior neuromuscular disease 5. Any degree of heart block 6. Chronic use of opioids 7. Pregnancy 8. Prior treatment with calcium channel blockers and betablockers. 9. Patients receiving magnesium supplementation.

Design outcomes

Primary

Measure	Time frame
Requirement of anesthetic agents: Timepoint: Requirement of anesthetic agents: 1. Propofol induction dose 2. Propofol maintenance dose(every 30 mins) 3. Fentanyl maintenance dose 4. Atracurium maintenance dose	—

Secondary

Measure	Time frame
Hemodynamic stability: 1. Heart rate 2. Blood pressure 3. Mean arterial pressure(MAP)Timepoint: 1. Preoperative 2. After study drug 3. After induction 4. After intubation 5. Intraoperative at 10 mins interval 6. After surgery 7. After extubation;Recovery indices: 1. Recovery time 2. Orientation time 3. Extubation time.Timepoint: 1. Time elapsed between stoppage of propofol infusion and a qCON value of 80 is Recovery time. 2. Time elapsed between stoppage of propofol infusion and response to verbal commands is Orientation time. 3. Time elapsed between stoppage of propofol infusion and extubation is extubation time.	—

Measure

Time frame

Hemodynamic stability: 1. Heart rate 2. Blood pressure 3. Mean arterial pressure(MAP)Timepoint: 1. Preoperative 2. After study drug 3. After induction 4. After intubation 5. Intraoperative at 10 mins interval 6. After surgery 7. After extubation;Recovery indices: 1. Recovery time 2. Orientation time 3. Extubation time.Timepoint: 1. Time elapsed between stoppage of propofol infusion and a qCON value of 80 is Recovery time. 2. Time elapsed between stoppage of propofol infusion and response to verbal commands is Orientation time. 3. Time elapsed between stoppage of propofol infusion and extubation is extubation time.

—

Countries

India

Contacts

Public ContactDr Sumesh Mathew

Jubilee Mission Medical College and Research Institute

sumesh.math@gmail.com8281917501

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026