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Comparing the amount of intravenous fluid required during surgery by using a variable derived from arterial blood pressure and conventional method by calculation of fluid and blood loss during surgery in brain surgeries done in supine position

Effect of Pulse Pressure Variance (PPV) guided fluid management on intra operative fluid requirement in supra tentorial tumour surgeries in supine position- A Prospective, double blind, Randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/04/018746
Enrollment
80
Registered
2019-04-24
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D496- Neoplasm of unspecified behavior of brain

Interventions

Intervention1: Internal jugular vein catheterisation, Radial artery cannulation, Intravenous fluid administration: Intravenous fluids plamalyte and normal saline will be given alternatively to maintai

Sponsors

SGPGI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2 patients, patients undergoing supra tentorial tumour surgery electively in supine position, patients who consented to take part in the study

Exclusion criteria

Exclusion criteria: Significant cardiac illness, Tumours prone to precipitate diabetes insipidus, Chronic obstructive airway disease, Peripheral vascular disease, Raised intra abdominal pressure, Patients in sepsis and on lactate producing drugs, Massive blood loss intra operatively (more than 50% of blood volume within 3 hours), Patients shifted on ventilatory support post operatively, Patients who refused to take part in the study

Design outcomes

Primary

MeasureTime frame
To compare the Total Intra operative fluid requirement using Pulse Pressure guided fluid management and fluid management using conventional method in supra tentorial tumour surgeries in supine positionTimepoint: Post extubation—

Secondary

MeasureTime frame
To compare Brain relaxation score between the two groupsTimepoint: At the time of opening of duramater by surgeon;To compare incidence of hypotension ( more than 20% fall from baseline BP) between the two groupsTimepoint: Entire intra operative period;To compare Serum lactate measurement between the two groupsTimepoint: Immediately after induction of anaesthesia, just prior to extubation and 24 hours after surgery;To compare the incidence of conjunctival and peri orbital edema between the two groupsTimepoint: Post extubation;To compare the incidence of post operative nausea and vomiting between the two groupsTimepoint: 24 hours after the surgery—

Countries

India

Contacts

Public ContactShashi Srivastava

Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow

shashian2014@gmail.com8004904594

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026