A comparison between zinc sulfate and magnesium sulfate gargle before operation to reduce sore throat after operation

A prospective, randomized, double blind, placebo controlled study between pre operative magnesium sulfate and zinc sulfate gargle for prevention of post operative sore throat following endotracheal intubation.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/04/018724

Enrollment

132

Registered

2019-04-24

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K802- Calculus of gallbladder without cholecystitis

Interventions

Intervention1: Gargle with magnesium sulfate solution and zinc sulfate solution for 30 seconds, 15 min before induction of anesthesia.: Patients in Group A will receive magnesium sulfate solution 20 m

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients giving valid consent 2.Patients undergoing ASA physical status I & II 3.Patients aged between 18 to 65 years of either sex. 4.Patient undergoing elective laparoscopic cholecystctomy under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1.Patientâ??s refusal. 2.Patients with ASA physical status III or more. 3.Patients posted for emergency surgery 4.Patients with history of alcohol or drug abuse. 5.Patients posted for airway related surgery 6.Pregnancy and lactating mother 7.History of recent sore throat, upper respiratory tract infection, common cold 8.Diabetic patients 9.Long term analgesic therapy 10.Patients with hypersensitivity or contraindication to magnesium or zinc 11.Any history of difficult intubation 12.Difficult intubation requiring more than one attempt 13.Patients with neurological ,psychiatric and neuromuscular disorder 14.Patients requiring introduction of Ryleâ??s tube in peri-operative period

Design outcomes

Primary

Measure	Time frame
To compare the effect of pre operative magnesium sulfate and zinc sulfate gargle on the incidence and severity of post operative sore throat following endotracheal intubation.Timepoint: July 2019-June 2020 (12 months)	—

Secondary

Measure	Time frame
1) Compare heart rate, mean arterial pressure, respiratory rate and oxygen saturation in post operative period among the study groups. 2) To observe the post operative nausea vomiting, pain, sedation and complications if any Timepoint: July 2019-June 2020 (12 months)	—

Countries

India

Contacts

Public ContactDebasish Bhar

Midnapore Medical College

debasish77bhar@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026