Role of lipid emulsion in organophosphate compound poisoning

To Study the Effects of Extended Doses of Lipid Emulsion in Organophosphate Compound Poisoning: Randomised Controlled Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/04/018699

Enrollment

Registered

2019-04-24

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T600- Toxic effect of organophosphate and carbamate insecticides

Interventions

Intervention1: 20% intralipid emulsion: bolus dose of 20% lipid emulsion 100ml over 1 hour followed by 20% lipid emulsion 100ml over 6 hours Control Intervention1: Normal Saline: 100ml of NS over 1 ho

Eligibility

Inclusion criteria

Inclusion criteria: 1. History of consumption of organophosphate compound. 2. Clinical manifestations of moderate or severe organophosphorus compound poisoning as per Peradeniya Severity Score. 3. Informed consent from the patient or next kin.

Exclusion criteria

Exclusion criteria: 1. Where the compound ingested could not be identified. 2. History of combined poisoning with a non-OP compound. 3. All other patients not fitting in the organophosphate symptom complex. 4. Patients having underlying kidney and liver ailments. 5. History suggestive of acute pancreatitis in the past.

Design outcomes

Primary

Measure	Time frame
To study the change in amount of atropine dose used after delivering extended doses of lipid emulsion in OP poisoned individuals. In test arm we will give 20% of 100ml Lipid emulsion over 1 hour followed by an infusion of the same over 6 hours. In control arm we will give 100ml of NS over 1 hour followed by 100ml NS over 6 hours.Timepoint: After 48 hours total dose of atropine required will be calculated	—

Measure

Time frame

To study the change in amount of atropine dose used after delivering extended doses of lipid emulsion in OP poisoned individuals. In test arm we will give 20% of 100ml Lipid emulsion over 1 hour followed by an infusion of the same over 6 hours. In control arm we will give 100ml of NS over 1 hour followed by 100ml NS over 6 hours.Timepoint: After 48 hours total dose of atropine required will be calculated

—

Secondary

Measure	Time frame
1. Hemodynamic parameters (pulse rate, systolic, diastolic blood pressures, mean arterial pressure and respiratory rate) 2. Duration of hospitalization 3. Duration of mechanical ventilation required 4. In-hospital 7 days mortality 5. 28th day mortality Timepoint: At 0 hour, 6 hours, 24 hours and 48 hours	—

Countries

India

Contacts

Public ContactSahil

PGIMER

bhalla.chd@gmail.com9914209536

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026