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Local Drug Delivery for the treatment of Periodontal Diseases

Comparison of Effectiveness of Subgingivally Delivered Boric acid gel and Curcumin gel as an adjunct to Mechanotherapy in Chronic Periodontitis: A clinical study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/04/018697
Enrollment
26
Registered
2019-04-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 3- Administration

Interventions

Intervention1: Boric acid gel: Based on the results of in vitro experiments, we will be using a 0.75% concentration of boric acid (pH 4.9) in this clinical study, but in gel form, for subgingival deli

Sponsors

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients motivated to have the therapy and willing to complete the follow-up. 2. Patients with a minimum of 20 teeth. 3. Subjects who readily give informed consent for the study. 4. Systemically healthy subjects, with deep pockets. 5. Patients with no history of periodontal therapy ij the preceding 6 months or under any antibiotic therapy.

Exclusion criteria

Exclusion criteria: 1. Patients on systemic boron therapy, those with a known or suspected allergy to boron supplementation or curcumin. 2. Patients who have undergone periodontal therapy in the last 6 months. 3. Patients who were taking and had consumed vitamin supplements, anti-inflammatory agents, or statins in the previous 3 months. 4. Patients with any systemic disorder affecting periodontal health. 5. Patients with infectious conditions other than periodontitis. 6. Regular users of mouthwashes. 7. Chronic alcoholics 8. Those with aggressive periodontitis. 9. Patients consuming tobacco in any form, smokers, alcoholics 10. Immunocompromised and systemically unhealthy patients. 11. Pregnant or lactating females.

Design outcomes

Primary

MeasureTime frame
Probing pocket depth reductionTimepoint: baseline, post-operatively 3 months and 6 months

Secondary

MeasureTime frame
Clinical attachment level gainTimepoint: baseline, post-operatively 3 months and 6 months

Countries

India

Contacts

Public ContactDr Ruchika Lulla

Sharad Pawar Dental College

priyanka.banode@gmail.com9960713010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026