Health Condition 1: C719- Malignant neoplasm of brain, unspecified
Conditions
Interventions
Intervention1: Diclofenac sodium: Analgesic efficacy of Paracetamol will be compared with Diclofenac sodium and need for rescue analgesia will be studied and rate of hematoma formation and platelet dy
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: Patients scheduled to undergo elective craniotomy for supratentorial tumours; ASA 1&2 patients; age 18-65 years of age
Exclusion criteria
Exclusion criteria: Pregnant/nursing women, BMI >35kg/m2; patients with difficult airway, H/O CHF, liver & kidney diseases, COPD, patients with poor GCS & severely raised ICP, Patient refusal, patients requiring >24hours postoperative mechanical ventilation and unable to communicate postoperatively
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare analgesic efficacy of diclofenacsodium sodium and paracetamol within first 48hours after supratentorial craniotomyTimepoint: To compare analgesic efficacy of diclofenacsodium sodium and paracetamol within first 48hours after supratentorial craniotomy | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of paracetamol and diclofenacsodium on 1) need for rescue analgesia; 2) coagulation profile and platelet function,3) incidence of hem atoms formation/expansion, 4) incidence of PONV, 5)duration of postoperative hospital stay, 6) effect on LFT&RFTTimepoint: Assesed at 12hours 24 hours and at 48hours postoperatively | — |
Countries
India
Contacts
Public ContactR Raj Kiran
Post graduate institute of medical education and research
Outcome results
None listed