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Effect of drugs like etomidate and thiopentone in depression patients undergoing electroshock therapy

Effect of intravenous thiopentone versus etomidate on modified electroconvulsive therapy in patients with major depressive disorder

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2019/04/018687
Enrollment
40
Registered
2019-04-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F339- Major depressive disorder, recurrent, unspecified

Interventions

Intervention1: Etomidate: 0.2mg/kg Of Intravenous Etomidate Control Intervention1: Thiopentone: 2.5% 3mg/kg Of Intravenous Thiopentone

Sponsors

Balapriya B
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients with Major depressive disorder 2) Patients of either sex 3) Age >18 or <55 in years

Exclusion criteria

Exclusion criteria: 1) Patients with physical status according to American society of anesthesiologist(ASA) 3 and 4 2) Patients with allergy to sulpha drugs 3) Patients with history of porphyria 4) Patients with history of asthma 5) Patients who have got contraindication for MECT ( Examples: Pheochromocytoma, signs of increased intracranial hypertension, recent myocardial infarction, recent stroke, adrenal insufficiency, uncontrolled hypertension, myocardial infarction, recent stroke, unruptured aneurysms, coagulopathies, unstable cervical spines/osteoporosis/bone fragility, patients with cardiac implantable devices) 6) Pregnant / Lactating women

Design outcomes

Primary

MeasureTime frame
Seizure DurationTimepoint: Total number of adequate seizure duration will be measured in seconds. Every 2 mins Blood pressure, Heart rate and SPO2 will be measured

Secondary

MeasureTime frame
Post anesthetic recovery score SedationTimepoint: Aldrets score Observers assessment of alertness/ sedation

Countries

India

Contacts

Public ContactBalapriya B

Sri Manakula Vinayagar Medical College

lazarus.suneeth@gmail.com9894332543

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026