Health Condition 1: C021- Malignant neoplasm of border of tongue Health Condition 2: C060- Malignant neoplasm of cheek mucosa Health Condition 3: C049- Malignant neoplasm of floor of mouth, unspecified Health Condition 4: C039- Malignant neoplasm of gum, unspecified Health Condition 5: C004- Malignant neoplasm of lower lip, inner aspect
Conditions
Interventions
None listed
Sponsors
University of Chicago Trust in India
Eligibility
Inclusion criteria
Inclusion criteria: 1) Oral Cavity Squamous cell carcinoma in Clinical stage I / II 2) Ability to understand the study and willing to give written informed consent 3) Eastern co-operative Oncology Group(ECOG) performance status 0-2 4) Treatment Naive patients. 5) Having primary treatment at Tata Memorial Centre
Exclusion criteria
Exclusion criteria: 1) Non-squamous histology 2) Underwent treatment for non OCSCC with any modality. 3) Underwent treatment for OCSCC with any modality. 4) Disease Recurrence and Second primary. 5) Not giving consent. 6) Pregnant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To Create a biomarker gene panel that contains the most commonly occurring mutations in OCSCC.A foundational biomarker gene panel will be created based on research work that defined the mutational landscape of Head Neck Squamous Cell Carcinoma. This panel of founder mutations will function as the biomarkers for released tumor DNA in saliva derived from Oral Cavity Squamous Cell Carcinoma patients.Timepoint: at the completion of the study - 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Validate founder mutations and evaluate the diagnostic and prognostic accuracy of rtDNA in saliva in the clinical settingTimepoint: 12 - 18 months | — |
Countries
India
Contacts
Public ContactDr Sudhir V Nair
Tata Memorial Centre, Mumbai
Outcome results
None listed