Comparison of two commonly used anaesthetic agents on the blood vessels in the brain of patients with brain bleed from thinned out blood vessels

Comparison of effects of Propofol and Sevoflurane on the cerebral vasculature assessed by Digital Subtraction Angiographic parameters in patients treated for ruptured Cerebral Aneurysm: a Prospective Randomised trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/04/018637

Enrollment

Registered

2019-04-16

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I607- Nontraumatic subarachnoid hemorrhage from unspecified intracranial artery

Interventions

Intervention1: Propofol: Assessment of effect of Propofol on the cerebral vasculature by Digital Subtraction Angiographic parameters in patients treated for ruptured Cerebral Aneurysm Control Interven

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with ruptured cerebral aneurysm scheduled for coil embolisation procedure 2. Age 18 years and above 3. WFNS grade 1and 2 patients36 /Modified Hunt and Hess Clinical Grade 1 and 2 patients 4. Modified Fisher grade 1 and 2 patients

Exclusion criteria

Exclusion criteria: 1. Hemodynamically unstable patients 2 Intubated patients 3. Patients receiving sedative agents 4. Patients diagnosed to have vasculitis 5. Patients diagnosed to have cerebral vasospasm clinically or radiologically 6. Hematocrit of less than 30% and more than 45%

Design outcomes

Primary

Measure	Time frame
To compare the effects of propofol (TIVA) and sevoflurane (VIMA) on the luminal diameter of cerebral vessels in patients undergoing endovascular embolisation for ruptured cerebral aneurysm.Timepoint: 1. Just prior to anaesthetic exposure 2. 60 minutes after induction of anaesthesia. 3. Just after the coiling procedure	—

Secondary

Measure	Time frame
2) To compare the changes on cerebral blood flow with propofol and sevoflurane by measuring cerebral transit time in patients undergoing endovascular embolisation for ruptured cerebral aneurysm.Timepoint: 1. Just prior to anaesthetic exposure 2. 60 minutes after induction of anaesthesia. 3. Just after the coiling procedure	—

Countries

India

Contacts

Public ContactSteve Joys

Postgraduate Institute of Medical Education and Research

stevejoys@gmail.com7087617352

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026