Health Condition 1: L980- Pyogenic granuloma
Conditions
Interventions
Intervention1: Timolol 0.5% long-acting aqueous solution: Topical application of 2 drops over the lesion twice daily for 6 weeks
Control Intervention1: Glycerine solution: Topical application of 2 dro
Sponsors
Indian Association of Dermatologists Venereologists and Leprologists Research grant
Eligibility
Inclusion criteria
Inclusion criteria: i. Clinically diagnosed cases of pyogenic granuloma over skin ii. Age 2 years to 65 years iii. Patients consenting/ assenting to participate in the trial and come for follow â?? up visits iv. Duration of skin lesion not more than 8 weeks
Exclusion criteria
Exclusion criteria: i. Age less than 2 years or more than 65 years ii. Mucosal pyogenic granuloma iii. Pregnant or lactating patients iv. Systemic comorbidities like cardiac problems (sinus bradycardia, 2nd or 3rd degree AV block, overt cardiac failure, cardiogenic shock), bronchial asthma, COPD, persistent hypoglycemia v. Patient on systemic beta-blockers, calcium channel blockers, quinidine, which have a significant interaction with topical timolol. vi. Use of any other treatment modality previously
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in size of the lesion in millimetersTimepoint: 0, 2, 4, 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Global assessment of improvement based on photographic evaluation â?? into 4 grades Grade 1- 75% improvement, Grade 2 â?? 50-75% improvement, Grade 3- 25-50% improvement and Grade 4 - 25% improvementTimepoint: 0, 2, 4, 6 weeks;Improvement in color will be expressed subjectively in terms of four grades: 1, 2, 3 and 4 where Grade 1 is complete improvement and return to skin color, while Grade 4 is â??no changeâ?? , with the lesion remaining redTimepoint: Baseline at 0 weeks and at 6 weeks;Patientâ??s global assessment regarding the improvement with the treatment (or parentâ??s in the case of patients less than 18 years) will be done on a five point scale â?? Grade 1 â?? Excellent, Grade 2 - Very good, Grade 3 - Good, Grade 4 â?? Poor, 5 - No changeTimepoint: 0, 2, 4, 6 weeks;Physiciansâ??s global assessment regarding the improvement with the treatment will be done on a five point scale â?? Grade 1 â?? Excellent, Grade 2 - Very good, Grade 3 - Good, Grade 4 â?? Poor, 5 - No changeTimepoint: 0, 2, 4, 6 weeks | — |
Countries
India
Contacts
Public ContactAmrita Sil
Bankura Sammilani Medical College
Outcome results
None listed